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Phillip Musich, Ph.D.
Professor
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| Room A025 Stanton Gerber Hall (Bldg. 178),
VA Medical Center
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Education
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1968 B.S., (cum laude)
Chemistry and Biology, Creighton University, Omaha,
Nebraska
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1973 Ph.D., Department
of Biology, University of Chicago, Illinois
Interdisciplinary
Association
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Director, Program in
Molecular Biology
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Adjunct Professor of
Biological Sciences, College of Arts & Sciences, ETSU
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Research Projects
Eukaryotic genomes are very complex but dynamic structures. We
are studying this dynamic flexibility and the role of oxidative DNA
damage in aging. As an experimental model system we employ the
dynamic L2Hs elements in human DNA and in recombinant DNA
constructs. The L2Hs sequences have undergone amplifications and
rearrangements in the evolution of human genomes. They are useful in
"DNA fingerprinting" individual humans and for following
the process of genomic DNA differentiation during the development of
cell lineages in embryogenesis and tumor oncogenesis. and in
tracking the effects of genomic damage. These properties are related
to the potential of L2Hs elements to form unusual DNA structures and
to affect the structure of adjacent chromosomal sequences. In a
related project, a prokaryotic "replicative evolution"
model system has been developed to study the stability of a
recombinant plasmid containing these dynamic sequences during normal
growth and in response to environmental oxidative challenge.
Selected Publications:
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Musich
PR, Chu W. |
Related
Articles,
Links |
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A hot alkaline plasmid DNA miniprep method for
automated DNA sequencing protocols.
Biotechniques. 1993 Jun;14(6):958-60.
PMID: 8333963 [PubMed - indexed for MEDLINE] |
This page was last updated 11/01/2005
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